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雌马酚
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首页 化学性质 94105-90-5
雌马酚
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CAS No. 94105-90-5
分子式 C15H14O3
分子量 242.27
英文名称 (+/-)-EQUOL
中文同义词 R,S-雌马酚;)-雌马酚;纳米脂质体雌马酚;(卤)-EQUOL;(+)-雌马酚;雌马酚,(±)-雌马酚;3-(4-羟基苯基)四氢苯并吡喃-7-醇;雌马酚 98% 不是S型,混旋的
基本信息
产品名称
雌马酚
中文同义词
R,S-雌马酚,)-雌马酚,纳米脂质体雌马酚,(卤)-EQUOL,(+)-雌马酚,雌马酚,(±)-雌马酚,3-(4-羟基苯基)四氢苯并吡喃-7-醇,雌马酚 98% 不是S型,混旋的
英文名称
(+/-)-EQUOL
英文同义词
7,4'-HoMoisoflavane;NV 07α;3-(4-Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol 7-Hydroxy-3-(4-hydroxyphenyl)chroman 4',7-Isoflavandiol;3,4-Dihydro-3-(4-hydroxyphenyl)-2H-chromen-7-ol, (+/-)-Equol, 4',7-Isoflavandiol, 7-Hydroxy-3-(4-hydroxyphenyl)chroman;4',7-Isoflavandiol, (+/-)-Equol;4′,7-Dihydroxyisoflavane;(+/-)-Equol (GMP);(±)-EQUOL >= 99.0% (TLC)
CAS No.
94105-90-5
分子式
C15H14O3
分子量
242.27
EINECS号
618-999-2
MDL NO.
MFCD00016662
MOL
94105-90-5.mol
性质
BRN
87752
密度
1.286±0.06 g/cm3(Predicted)
形态
Crystalline powder
沸点
441.7±45.0 °C(Predicted)
熔点
158-160?C
InChIKey
ADFCQWZHKCXPAJ-UHFFFAOYSA-N
敏感性
Hygroscopic
溶解度
soluble in Ethanol
酸度系数(pKa)
9.94±0.40(Predicted)
颜色
White to Light yellow to Light red
储存条件
Inert atmosphere,Store in freezer, under -20°C
水溶解性
Soluble in DMSO and methanol or 100% ethanol. Insoluble in water.
用途
体内研究
Equol is a modest natriuretic and vasorelaxant agent in the rat. Orally administered equol is about 8-fold less potent than orally administered furosemide. In isolated aortic rings precontracted by administration of phenylephrine, administration of equol relaxes the contracted aorta (concentration for half-maximal activity 58.9±16 μM). Equol possesses anticancer activity that suppresses tumor formation via apoptosis induction in rats with DMBA-induced mammary gland tumors. In addition, equol shows a hepatic protective effect by acting as an antioxidant and by reducing apoptosis.
体外研究
Equol is first isolated and identified from pregnant-mares' urine and later found in the urine of the goat, cow, hen and sheep. Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers. S-equol is the exclusive product of human intestinal bacterial synthesis from soy isoflavones and both enantiomers are bioavailable. S-equol has a high affinity for estrogen receptor beta (K i =0.73 nM), whereas R-equol is relatively inactive. Equol could promote the proliferation and differentiation of rat osteoblasts through activating the ER-PKCα-related signaling pathway. The alkaline phosphatase activity also increases significantly in all of the equol and 17β-estradiol (E2 ) groups. Equol also significantly elevates the osteocalcin levels.
生物活性
(±)-Equol是equol的外消旋体。 Equol是大豆异黄酮黄豆苷和大豆黄素的代谢产物。
安全信息
WGK Germany
3
海关编码
2932999099
编辑结构
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南京恩明医药科技有限公司
13305188663 025-025-58894663
中文名称：
雌马酚
英文名称：
(+/-)-EQUOL
CAS NO.：
94105-90-5
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武汉麦可欣科技有限公司
13476159580 027-85785063
中文名称：
雌马酚
英文名称：
(+/-)-EQUOL
CAS NO.：
94105-90-5
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重庆酞之泉生物科技有限公司
18306022109
中文名称：
雌马酚
英文名称：
(+/-)-EQUOL
CAS NO.：
94105-90-5
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