体外研究
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC
50
of 720 nM. FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC
50
s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC
50
s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC
50
of 15 μM.
编辑结构
