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二盐酸奎吖因水合物
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基本信息
性质
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二盐酸奎吖因水合物
查看26 家供应商 暂无价格
CAS No. 69-05-6
分子式 C23H32Cl3N3O
分子量 472.88
英文名称 QUINACRINE DIHYDROCHLORIDE
中文同义词 疟疾平;二盐酸喹吖因;喹吖因二盐酸;阿的平 二盐酸盐;二盐酸阿的平;二盐酸喹丫因;疟涤平;盐酸阿的平
基本信息
产品名称
二盐酸奎吖因水合物
中文同义词
疟疾平,二盐酸喹吖因,喹吖因二盐酸,阿的平 二盐酸盐,二盐酸阿的平,二盐酸喹丫因,疟涤平,盐酸阿的平
英文名称
QUINACRINE DIHYDROCHLORIDE
英文同义词
6-CHLORO-9-(4-DIETHYLAMINO-1-METHYL-BUTYLAMINO)-2-METHOXYACRIDINE DIHYDROCHLORIDE;6-CHLORO-9-(4-DIETHYLAMINO-1-METHYL-N-BUTYL)AMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE;ERION HYDROCHLORIDE;DL-QUINACRINE HYDROCHLORIDE;CHINACRIN HYDROCHLORIDE;CHEMIOCHIN HYDROCHLORIDE;ARICHIN HYDROCHLORIDE;ATABRINE HYDROCHLORIDE
CAS No.
69-05-6
分子式
C23H32Cl3N3O
分子量
472.88
EINECS号
200-700-8
MDL NO.
MFCD00150069
性质
BRN
4834013
Merck
14,8044
PH值
3.0~5.0 (20g/l, 25℃)
密度
1.2962 (rough estimate)
形态
Yellow solid
熔点
249-251℃ (Decomposition)
颜色
Light Yellow to Yellow
折射率
1.6300 (estimate)
储存条件
+15C to +30C
水溶解性
Water: 33.33 mg/mL (70.48 mM)
溶解度
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
稳定性
Stable. Incompatible with strong oxidizing agents.
酸度系数(pKa)
pKa -6.3(H2O t undefined I not reported but low) (Uncertain)
EPA化学物质信息
Quinacrine hydrochloride (69-05-6)
用途
类别
有毒物质
靶点
TargetValue PLA2 ()
灭火剂
水, 二氧化碳, 泡沫, 沙土
体内研究
Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose. Animal Model: Female SCID mice with acute myeloid leukemia (AML)-PS model Dosage: 100 mg/kg Administration: Administered by oral gavage (po); three times a week for two consecutive weeks Result: In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%. The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
体外研究
Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells. Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway. Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis . Cell Viability Assay Cell Line: SGC-7901 cells Concentration: 0, 5, 10, 15, and 20 μM Incubation Time: 24 hours Result: Cell viability was inhibited in a dose-dependent manner, and the mean IC 50 value is 16.18 μM. Apoptosis Analysis Cell Line: SGC-7901 cells Concentration: 7.5 and 15 μM Incubation Time: 24 hours Result: The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%. Western Blot Analysis Cell Line: SGC-7901 cells Concentration: 15 μM Incubation Time: 24 hours Result: The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24. The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19. The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.
储运特性
库房低温, 通风, 干燥
急性毒性
口服- 大鼠 LD50: 660 毫克/ 公斤; 口服- 小鼠 LD50: 557 毫克/ 公斤
毒性分级
中毒
生物活性
Quinacrine 2HCl是具有多种作用的亲脂性阳离子药物,通常用作抗原生动物剂。Quinacrine是有效的phospholipase A2抑制剂。
可燃性危险特性
可燃;火场释放有毒氮氧化物, 氯化物烟雾
安全信息
毒性
LD50 oral in rabbit: 433mg/kg
RTECS号
AR7875000
WGK Germany
3
安全说明
危险品标志
Xn
危险类别码
海关编码
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185-0276
中文名称:
二盐酸奎吖因水合物
英文名称:
QUINACRINE DIHYDROCHLORIDE
CAS NO.:
69-05-6
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中文名称:
二盐酸奎吖因水合物
英文名称:
QUINACRINE DIHYDROCHLORIDE
CAS NO.:
69-05-6
联系我们:
QQ
QQ号: 3191742441 复制
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微信洽谈
18642120371 13552411355
中文名称:
二盐酸奎吖因水合物
英文名称:
QUINACRINE DIHYDROCHLORIDE
CAS NO.:
69-05-6
联系我们:
QQ
QQ号: 2837458851 复制
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