Acetylcholine chloride (ACh chloride; SC; 20 mg/kg; single dose) induces pronounced cholinergic stimulation and increase of mouse survival in experimental infection.
Animal Model:
Male and female out-bred albino mice weighing 18-22 g (sepsis)
Dosage:
20 mg/kg
Administration:
SC; single dose
Result:
Significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×10
9
E. coli
bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.
体外研究
Acetylcholine chloride (ACh chloride; 10 μM) opens the calcium channel and the fluorescence value and intracellular free calcium will increase significantly when the medium is with high calcium, while these will decrease when the medium is without calcium in sweat gland epithelial cells.
编辑结构
