Stable. Incompatible with strong oxidizing agents.
水溶解性
Soluble in 1M HCl at 50mg/ml. Soluble in water at 0.7mg/ml. Also soluble in DMSO
CAS 数据库
59277-89-3(CAS DataBase Reference)
酸度系数(pKa)
pKa 2.27 (Uncertain);9.25 (Uncertain)
用途
用途
一种鸟苷类似物，作为抗代谢物。Acyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects through the alterations of the cell cycle in leukemia cells lines, such as p185BCR-ABL expressing OM9;22 cells, by synchronizing the G0/G1 phase. Formation of acycloguanosine triphosphate occurs through the phosphorylation of HSV-TK and can inhibit the viral DNA polymerase. Acyclovir also has the ability to inhibit the proliferation of the fibroblast cells, NIH 3T3, transformed with v-abl or bcr-abl.
编辑结构
