Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells. Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model) Dosage: 600 mg/kg Administration: Oral administration; daily; for 21 days Result: Markedly and significantly inhibited tumour growth.

Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC 50 of ~40 μM. Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis. Cell Viability Assay Cell Line: Jurkat cells Concentration: 25 μM, 50 μM, 75 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner. Western Blot Analysis Cell Line: Jurkat cells Concentration: 25 μM, 50 μM Incubation Time: 72 hours Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.

Minerval (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物，能与质膜结合改变脂质组织。Minerval 具有抗肿瘤作用。