体外研究
Cefuroxime is highly active against
S. aureus
(MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is against
Staphylococcus aureus
methicillin susceptible;
S. aureus
, methicillin resistant,
Streptococcus pyogenes
,
S. pneumoniae
,
S. viridans
,
S. faecalis
, and
Clostridium spp
with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively.
Cefuroxime (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains of
S. aureus
, but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains.
编辑结构
