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三七素

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三七素

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CAS No. 5302-45-4

分子式 C5H8N2O5

分子量 176.13

英文名称 3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID

中文同义词 3-[(羧基羰基)氨基]-L-丙氨酸;3-N-草酰-L-2,3-二氨基丙酸;L-三七素;Β-N-OXALYLAMINO-L-ALANINE 三七素;三七素(3-N-草酰-L-2,3-二氨基丙酸);三七素(3-N-草酰-L-2;山黎豆素;田七素

基本信息

产品名称

三七素

中文同义词

3-[(羧基羰基)氨基]-L-丙氨酸,3-N-草酰-L-2,3-二氨基丙酸,L-三七素,Β-N-OXALYLAMINO-L-ALANINE 三七素,三七素(3-N-草酰-L-2,3-二氨基丙酸),三七素(3-N-草酰-L-2,山黎豆素,田七素

英文名称

3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID

英文同义词

3-N-OXALYL-L-2,3-DIAMINOPROPANOICACID;BETA-N-OXALYL-ALPHA,BETA-DIAMINOPROPIONICACID;BETA-N-OXALAMINO-L-ALANINE;BETA-N-OXYALYLAMINE-L-ALANINE;(S)-2-Amino-3-[(1,2-dioxo-2-hydroxyethyl)amino]propionic acid;Dencichin;ODAP;β-L-ODAP

CAS No.

5302-45-4

分子式

C5H8N2O5

分子量

176.13

EINECS号

MDL NO.

MFCD00055228

MOL

5302-45-4.mol

性质

形态

powder

颜色

white to beige

酸度系数(pKa)

1.99±0.10(Predicted)

密度

1.596±0.06 g/cm3 (20 ºC 760 Torr)

溶解度

0.1 M HCl: soluble2mg/mL, clear (warmed)

储存条件

Keep in dark place,Sealed in dry,2-8°C

旋光性 (optical activity)

[α]/D -17 to -23°, c = 0.5 (Solvent: 4N HCl)

用途

用于含量测定/鉴定/药理实验等。

靶点

PHD-2

体内研究

Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models.

体外研究

Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN).

化学性质

无色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于三七干燥根。

生物活性

Dencichin 是从三七中分到的非蛋白氨基酸，能够抑制 HIF-prolyl hydroxylase-2 (PHD-2) 的活性。

编辑结构

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