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硫坎酮

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编辑结构

硫坎酮

查看29 家供应商

暂无价格

CAS No. 479-50-5

分子式 C20H24N2OS

分子量 340.48

英文名称 lucanthone

中文同义词 1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮;甲硫蒽酮;硫蒽酮;硫坎酮;APE-1抑制剂(LUCANTHONE);甲硫恩酮;1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮

基本信息

产品名称

硫坎酮

中文同义词

1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮,甲硫蒽酮,硫蒽酮,硫坎酮,APE-1抑制剂(LUCANTHONE),甲硫恩酮,1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮

英文名称

lucanthone

英文同义词

lucanthone;1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one;Lycanthone;1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one;Lucanthonum;Lucantona;9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-;Autophagy,inhibit,Lucanthone,Inhibitor

CAS No.

479-50-5

分子式

C20H24N2OS

分子量

340.48

EINECS号

207-532-4

MDL NO.

MFCD00866726

MOL

479-50-5.mol

性质

密度

1.0915 (rough estimate)

形态

固体

沸点

512.4±50.0 °C(Predicted)

熔点

64.5°C

颜色

米白色至橙色

折射率

1.5950 (estimate)

储存条件

Store at -20°C

酸度系数(pKa)

10.00±0.25(Predicted)

溶解度

二甲基亚砜：25 mg/mL（73.43 mM）

用途

靶点

APE-1

体外研究

Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC 50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.

生物活性

Lucanthone是新型的自噬抑制剂，也是可用于口服的DNA嵌入剂、DNA修复酶APE1的抑制剂。

编辑结构

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