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DL-肉碱盐酸盐
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性质
用途
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编辑结构
首页 化学性质 461-05-2
DL-肉碱盐酸盐
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CAS No. 461-05-2
分子式 C7H16ClNO3
分子量 197.66
英文名称 DL-Carnitine hydrochloride
中文同义词 DL-肉碱盐酸盐, 98+%;DL-卡尼汀盐酸;DL-肉碱盐酸盐饲料级;DL-肉碱盐酸盐医药级;混旋肉堿盐酸盐;DL-肉碱盐酸盐(>98%,BR);混旋肉碱盐酸盐(99%);混旋肉碱盐酸盐
基本信息
产品名称
DL-肉碱盐酸盐
中文同义词
DL-肉碱盐酸盐, 98+%,DL-卡尼汀盐酸,DL-肉碱盐酸盐饲料级,DL-肉碱盐酸盐医药级,混旋肉堿盐酸盐,DL-肉碱盐酸盐(>98%,BR),混旋肉碱盐酸盐(99%),混旋肉碱盐酸盐
英文名称
DL-Carnitine hydrochloride
英文同义词
(2,4-dihydroxy-4-keto-butyl)-trimethyl-ammonium chloride;(2,4-dihydroxy-4-oxo-butyl)-trimeth;(2,4-dihydroxy-4-oxo-butyl)-trimethyl-ammonium chloride;(2,4-dihydroxy-4-oxobutyl)-trimethylammonium chloride;3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride;3-hydroxy-4-trimethylazaniumylbutanoate hydrochloride;3-hydroxy-4-trimethylazaniumyl-butanoate hydrochloride;dl-bicarnesine hydrochloride
CAS No.
461-05-2
分子式
C7H16ClNO3
分子量
197.66
EINECS号
207-309-1
MDL NO.
MFCD00011904
MOL
461-05-2.mol
性质
BRN
4163212
Merck
14,1849
PH值
1.8-2.5 (100g/l, H2O)
熔点
197-199 °C
颜色
White to almost white
InChIKey
JXXCENBLGFBQJM-UHFFFAOYSA-N
敏感性
Hygroscopic
稳定性
Hygroscopic
储存条件
Store below +30°C.
水溶解性
SOLUBLE
形态
Powder, Crystals, Needles and/or Chunks
溶解度
Aqueous Base (Slightly), Methanol (Slightly, Heated), Water (Sparingly, Sonicate
比旋光度
-0.2～+0.2°(20℃/D)(c=5,H2O)
CAS 数据库
461-05-2(CAS DataBase Reference)
EPA化学物质信息
1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride (1:1) (461-05-2)
用途
性状
白色结晶或结晶性粉末
用途
用于医药、水产饲料添加营养剂等
类别
有毒物质
灭火剂
水,二氧化碳, 泡沫, 干粉
体内研究
L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ.
体外研究
The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H 2 O 2 -treated HL7702 cells. L-carnitine protects HL7702 cells against H 2 O 2 -induced cell damage through Akt-mediated activation of Nrf2 signaling pathway.
储运特性
库房低温通风干燥
急性毒性
皮下-大鼠 LD50: 10000 毫克/公斤; 皮下-小鼠 LD50: 6000 毫克/公斤
毒性分级
低毒
生物活性
DL-肉碱盐酸盐是氨基酸赖氨酸和蛋氨酸生物合成的一种季铵化合物。
可燃性危险特性
热分解排出有毒氮氧化物, 氯化物烟雾
安全信息
TSCA
Yes
RTECS号
BP2979140
WGK Germany
3
安全说明
26-36-37/39
海关编码
2918990090
危险品标志
Xi
危险类别码
36/37/38
毒性
LD50 subcutaneous in mouse: 6gm/kg
编辑结构
供应商 查看全部供应商
湖北恒硕化工有限公司
13986271535;13607132287 027-82200625;82830253
中文名称：
DL-肉碱盐酸盐
英文名称：
DL-Carnitine hydrochloride
CAS NO.：
461-05-2
联系我们：
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湖北天盟化工有限责任公司
13085226925 027-86752516
中文名称：
DL-肉碱盐酸盐
英文名称：
DL-Carnitine hydrochloride
CAS NO.：
461-05-2
安琪酵母股份有限公司
0717-6370393 4008873298
中文名称：
DL-肉碱盐酸盐
英文名称：
DL-Carnitine hydrochloride
CAS NO.：
461-05-2
信息错误报告 461-05-2
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