Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery.
Animal Model:
Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO)
Dosage:
50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg
Administration:
Intraperitoneal injection; once
Result:
Dose-dependently reduced the infarct volume after MCAO.
体外研究
Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane.
编辑结构
