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adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid

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adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid

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CAS No. 3469-78-1

分子式 C11H18N5O12P3

分子量 505.21

英文名称 adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid

中文同义词化合物 T13547

基本信息

产品名称

adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid

中文同义词

化合物 T13547

英文名称

adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid

英文同义词

adenosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid;5'-adenylyl (beta,gamma-methylene)diphosphonate;5'-Adenylic acid (phosphonomethyl)phosphonyl ester;Adenylyl methylenediphosphonate;AMP-P(CH2)P;β,γ-Methylene ATP;β,γ-MethyleneATP;5'-Adenylic acid, monohydride with methylenebis(phosphonic acid)

CAS No.

3469-78-1

分子式

C11H18N5O12P3

分子量

505.21

EINECS号

222-435-7

MDL NO.

MOL

3469-78-1.mol

性质

密度

2.50±0.1 g/cm3(Predicted)

沸点

968.2±75.0 °C(Predicted)

酸度系数(pKa)

0.68±0.10(Predicted)

用途

靶点

HSP90 3.8 μM (Kd)

体外研究

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.

生物活性

AMP-PCP 是一种 ATP 类似物，可以以 Kd 值为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP 结合有利于 Hsp90 活性同型二聚体的形成。

编辑结构

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