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2H4]-D,L-2-羟基戊二酸

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2H4]-D,L-2-羟基戊二酸

查看4 家供应商

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CAS No. 2889-31-8

分子式 C5H8O5

分子量 148.11

英文名称 C02630

中文同义词

基本信息

产品名称

2H4]-D,L-2-羟基戊二酸

中文同义词

英文名称

C02630

英文同义词

C02630;alpha-hydroxyglutarate;2,3-Dideoxypentaric Acid;a-Hydroxyglutaric Acid;DL-2-Hydroxyglutaric Acid;2-hydroxyglutarate;α-Hydroxyglutaric Acid

CAS No.

2889-31-8

分子式

C5H8O5

分子量

148.11

EINECS号

MDL NO.

MFCD18642138

MOL

2889-31-8.mol

性质

密度

1.508±0.06 g/cm3(Predicted)

沸点

394.2±27.0 °C(Predicted)

酸度系数(pKa)

3.67±0.10(Predicted)

熔点

98-100 °C(Solv: ethyl acetate (141-78-6))

用途

体外研究

Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases. Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin.

生物活性

α-Hydroxyglutaric acid (2-Hydroxyglutarate) 是戊二酸的 α-羟基酸形式。α-Hydroxyglutaric acid 是多种 α-酮戊二酸依赖性双加氧酶 (包括 histone demethylases 和 5-甲基胞嘧啶羟化酶 (5-methlycytosine (5mC) hydroxylases) 的 TET 家族) 的竞争性抑制剂。

编辑结构

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