Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally.
体外研究
Aurora inhibitor 1 (Compound 16) exhibits K
d
values of 0.01 nM for both Aurora A and Aurora B kinase.
生物活性
Aurora inhibitor 1 是一种有效的 Aurora 抑制剂，抑制 Aurora A 和 Aurora B 激酶的 IC50 分别 ≤4 nM 和 ≤13 nM。
编辑结构
