具有抑制脂多糖诱导的icam-1表达和白细胞与脑内皮细胞粘附的作用

IC50: 7.92 μM (OVCAR-8 cell)

Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing. Animal Model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g) Dosage: 20 mg/kg Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours Result: Increased in blood glucose levels.

Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively. Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation. Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway. Cell Proliferation Assay Cell Line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells Concentration: 6.0-48.0 μM Incubation Time: 72 hours Result: Inhibited the proliferation of human cancer cells. Western Blot Analysis Cell Line: OVCAR-8 or PC3 cells Concentration: 0 μM, 6 μM, 12 μM, and 18 μM Incubation Time: 6 hours Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner. Apoptosis Analysis Cell Line: OVCAR-8 cells and PC3 cells Concentration: 0 μM, 6 μM, 12 μM, and 18 μM Incubation Time: 72 hours Result: Led to dose dependent increase of apoptosis.

黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于补骨脂PsoraleacorylifoliaLinn.。

Isobavachalcone (Corylifolinin) 来源于补骨脂，是一种 Akt 信号通路的有效抑制剂，可诱导人类癌细胞凋亡 (以 IC50 值为 7.92 μM 抑制 OVCAR-8 癌细胞生长)，具有抗癌和抗增殖活性。Isobavachalcone 还能诱导 OVCAR-8 细胞中活性氧的产生。