SulfaMethazine sodiuM pyriMidine;(n(sup1)-(4,6-dimethyl-2-pyrimidinyl)sulfanilamido)-sodiu;4-amino-n-(4,6-dimethyl-2-pyrimidinyl)-benzenesulfonamidmonosodiumsalt;sodiumsulphamezathine;sulfamethazinesodium;sulmet;vesadin;4-AMINO-N-[4,6-DIMETHYL-2-PYRIMIDINYL]BENZENE-SULFONAMIDE SODIUM SALT
Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt (1981-58-4)
用途
用途
一种抗菌磺胺药，诱导CYP3A4表达，以及通过N-乙酰转移酶乙酰化
靶点
Bacterial
体内研究
Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC
0->∞
, significantly increases t
1/2
α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01.
Animal Model:
19 healthy female pigs (6-week-old, 4.5-6.2 kg)
Dosage:
80 mg/kg
Administration:
Intravenous injection (Pharmacokinetic study)
Result:
The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC
0->∞
were significantly decreased and t
1/2
α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.
编辑结构
