2-mercaptoethanesulfonic;2-mercaptoethanesulfonicacidmonosodiumsalt;MERCAPTOETHANESULFONIC ACID SODIUM SALT;MESNA SODIUM SALT;MESNEX;MESNA;COENZYME M SODIUM SALT;HS-COM NA
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane
稳定性
Stable. Incompatible with strong oxidizing agents.
水溶解性
Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).
CAS 数据库
19767-45-4(CAS DataBase Reference)
用途
用途
呼吸系统用药。
体内研究
Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury.
Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats.
Animal Model:
Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI)
Dosage:
150 mg/kg
Administration:
A single i.p.
Result:
Decreased tissue malondialdehyde levels.
Increased the activity of glutathione peroxidase and superoxide dismutase.
Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase.
Protected the brain tissues well from injury.
体外研究
Mesna (1-1000 μM) reduces H
2
O
2
, HOCl and OH• concentrations in a dose-dependent manner, with an IC
50
of 32, 21, and 305 μM, respectively in cell-free experiments.
编辑结构
