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克拉司酮

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编辑结构

克拉司酮

查看33 家供应商

暂无价格

CAS No. 19608-29-8

分子式 C24H34O5

分子量 402.52

英文名称 Clascoterone

中文同义词 21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮;克拉司酮;克拉斯酮;CLASCOTERONE原料药;克拉考特酮;98.5%克拉司酮;Ⅰ晶型,白色或类白色结晶;皮质醇 17Α-丙酸酯

基本信息

产品名称

克拉司酮

中文同义词

21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮,克拉司酮,克拉斯酮,CLASCOTERONE原料药,克拉考特酮,98.5%克拉司酮,Ⅰ晶型,白色或类白色结晶,皮质醇 17Α-丙酸酯

英文名称

Clascoterone

英文同义词

17alpha-propio17-(1-oxopropoxy)pregn-4-ene-3,20-dione;CB-03-01 17alpha-propionate;Cortexolone 17-alpha-propionate;17 alpha-propionate (CB-03-01);21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione;(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate;Clascoterone;CB-03-01;CORTEXOLONE 17Α-PROPIONATE;CORTEXOLONE 17 ALPHA-PROPIONATE

CAS No.

19608-29-8

分子式

C24H34O5

分子量

402.52

EINECS号

685-282-9

MDL NO.

MFCD18384978

MOL

19608-29-8.mol

性质

密度

1.19

沸点

538.9±50.0 °C(Predicted)

溶解度

Soluble in DMSO

酸度系数(pKa)

12.98±0.10(Predicted)

用途

信号转导通路激酶抑制剂

靶点

TargetValue AR ()

体内研究

Clascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

生物活性

Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) 是一种局部的和外周选择性的 androgen receptor (AR) 的拮抗剂。

安全信息