Sigma-1 receptor, muscarinic receptor

Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration. Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice. Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response. Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice. Animal Model: Female Mecp2 tm1.1Bird /J HET (C57 background) mice Dosage: 10 mg/kg, 30 mg/kg Administration: Oral administration, daily, for 6.5 weeks Result: Reverse the deficits observed in the HET animals.

Blarcamesine (AVex-73;AE-37) 是一种 Sigma-1 受体激动剂和毒蕈碱受体 (muscarinic receptor) 调节剂，具有抗惊厥、抗失忆、神经保护和抗抑郁的特性。Blarcamesine 能改善 Rett 综合征小鼠模型的神经功能损害。