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PREGNENOLONE MONOSULFATE SODIUM SALT

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PREGNENOLONE MONOSULFATE SODIUM SALT

查看12 家供应商

暂无价格

CAS No. 1852-38-6

分子式 C21H31NaO5S

分子量 418.52

英文名称 PREGNENOLONE SULFATE SODIUM SALT

中文同义词孕烯醇酮硫酸钠盐;未标记的孕烯醇硫酸盐;孕烯醇硫酸盐 (20,21-13C2,99%;化合物 T16574

基本信息

产品名称

PREGNENOLONE MONOSULFATE SODIUM SALT

中文同义词

孕烯醇酮硫酸钠盐,未标记的孕烯醇硫酸盐,孕烯醇硫酸盐 (20,21-13C2,99%,化合物 T16574

英文名称

PREGNENOLONE SULFATE SODIUM SALT

英文同义词

PREGNENOLONE SULFATE SODIUM;PREGNENOLONE SULFATE SODIUM SALT;PREGNENOLONE SULPHATE, SODIUM SALT;3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT;3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT;3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT;5-PREGNEN-3BETA-OL-20-ONE SULFATE SODIUM SALT;5-PREGNEN-3-BETA-OL-20-ONE SULPHATE, SODIUM SALT

CAS No.

1852-38-6

分子式

C21H31NaO5S

分子量

418.52

EINECS号

MDL NO.

MFCD00056177

MOL

1852-38-6.mol

性质

熔点

192 °C(lit.)

溶解度

methanol and water: 1.93 mg/mL

用途

靶点

CB1 Human Endogenous Metabolite

体内研究

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se . Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.

体外研究

CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy. The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).

生物活性

Pregnenolone monosulfate sodium salt (3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt) 是一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone monosulfate sodium salt 是大麻素 CB1 受体的信号传导特异性抑制剂，抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。Pregnenolone monosulfate sodium salt 可以保护大脑免受大麻毒性的侵袭。

安全信息