体外研究
Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na
+
and Ca
2+
accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H
2+
O
2+
. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca
2+
in cardiac myocytes through inhibition of Na
+
/H
+
exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
编辑结构
