体外研究
BS-181 promotes cell cycle arrest and inhibits cancer cell growth, and growth is inhibited for all cell lines tested, with IC
50
values ranging from 11.5 to 37 μM. BS-181 inhibits RB phosphorylation at Ser
795
and Ser
821
with an apparent IC
50
of 15 μM, similar to the IC
50
obtained for P-Ser2 inhibition. BS-181 treatment of MCF-7 cells leads to G1 arrest at and apoptosis. BS-181 inhibits GC cell and normal gastric epithelial RGM-1 cell line growth with inhibitory concentration (IC
50
) ranging from 17 to 22 μM and 6.5 μM, respectively. BS-181 significantly inhibits cell migration and invasion ability in a dose-dependent manner.
编辑结构
