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坡模酸

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坡模酸

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CAS No. 13849-91-7

分子式 C30H48O4

分子量 472.7

英文名称 POMOLIC ACID

中文同义词坡模醇酸;坡模酸;坡模醇酸,坡模酸;兰地酸A;(1R,2R,4AS,6AS,6BR,8AR,10S,12AR,12BR,14BS)-1,10-二羟基-1,2,6A,6B,9,9,12A-七甲基-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-十八氢苉-4A(2H)-羧酸

基本信息

产品名称

坡模酸

中文同义词

坡模醇酸,坡模酸,坡模醇酸,坡模酸,兰地酸A,(1R,2R,4AS,6AS,6BR,8AR,10S,12AR,12BR,14BS)-1,10-二羟基-1,2,6A,6B,9,9,12A-七甲基-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-十八氢苉-4A(2H)-羧酸

英文名称

POMOLIC ACID

英文同义词

POMOLIC ACID;3β,19-Dihydroxy-5α-urs-12-en-28-oic acid;3β,19-Dihydroxyurs-12-en-28-oic acid;3β,19α-Dihydroxyurs-12-ene-28-oic acid;Benthamic acid;Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3β)-;Randialic acid A;(1R,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-1,10-Dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid

CAS No.

13849-91-7

分子式

C30H48O4

分子量

472.7

EINECS号

MDL NO.

MFCD04039823

性质

密度

1.14±0.1 g/cm3(Predicted)

沸点

586.2±50.0 °C(Predicted)

酸度系数(pKa)

4.48±0.70(Predicted)

熔点

297-299 °C(Solv: chloroform (67-66-3); methanol (67-56-1))

用途

靶点

IC50: apoptosis

体外研究

Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation. Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9.

生物活性

Randialic acid A (Pomolic acid) 是一种五环三萜烯，是从 Euscaphis japonica 中分离出来的。Randialic acid A (Pomolic acid) 抑制肿瘤细胞的生长并诱导细胞凋亡。 Randialic acid A (Pomolic acid) 有用于前列腺癌的潜力。

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