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L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
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基本信息
性质
用途
安全信息
编辑结构
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
查看25 家供应商 暂无价格
CAS No. 134448-10-5
分子式 C18H29N3O6
分子量 383.44
英文名称 CA-074
中文同义词 (L-3-反式-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸;CATHEPSIN B抑制剂(CA-074);(S)-1-((2S,3S)-3-甲基-2-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-甲酰胺基)戊酰基)吡咯烷-2-羧酸;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH;CA-074(L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE);N-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸
基本信息
产品名称
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
中文同义词
(L-3-反式-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸,CATHEPSIN B抑制剂(CA-074),(S)-1-((2S,3S)-3-甲基-2-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-甲酰胺基)戊酰基)吡咯烷-2-羧酸,L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH,CA-074(L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE),N-((2S,3S)-3-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮氨酰-L-脯氨酸
英文名称
CA-074
英文同义词
N-(L-3-TRANS-PROPYLCARBAMOYL-OXIRANE-2-CARBONYL)-ILE-PRO-OH;L-trans-Epoxysuccinyl(propylamide)-Ile-Pro;N-(L-3-trans-PropylcarbaMoyl-oxirane-2-carbonyl)-Ile-Pro-OH, CA-074, L-trans-Epoxysuccinyl(propylaMide)-Ile-Pro-OH;INHIBITOR FOR CATHEPSIN B;CATHEPSIN B INHIBITOR III;CA-074;[L-3-TRANS-(PROPYLCARBAMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE;(L-3-TRANS-(PROPYLCARBAMYL)OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE
CAS No.
134448-10-5
分子式
C18H29N3O6
分子量
383.44
EINECS号
200-258-5
MDL NO.
MFCD00797531
性质
密度
1.267±0.06 g/cm3(Predicted)
形态
solid
沸点
728.9±60.0 °C(Predicted)
储存条件
-20°C
酸度系数(pKa)
3.43±0.20(Predicted)
溶解度
Soluble in methanol at 1mg/ml. Also soluble in DMSO or ethanol.
用途
靶点
Ki: 2 to 5 nM (Cathepsin B)
体内研究
Intraperitoneally injection of compound CA-074 into rats potently and selectively inhibits cathepsin B activity. Intravenously administration of CA-074 immediately after the ischaemic insult saves 67% of CA1 neurons from delayed neuronal death on day 5 in eight monkeys undergoing 20 min brain ischaemia: the extent of inhibition is excellent in three of eight and good in five of eight monkeys.
体外研究
CA-074 is a synthetic analogue of E-64, a natural peptidyl epoxide that irreversibly inhibits most known lysosomal cysteine proteinases, and is developed by means of rational drug design, exploiting the dipeptidylcarboxypeptidase activity of cathepsin B. CA-074 can be used to selectively inhibit cathepsin B within living cells, as long as the experimental conditions permit significant fluid-phase endocytosis of the drug. CA-074 inhibits cathepsin B with a K i of 2 to 5 nM, whereas the initial K i s for cathepsin H and L are about 40-200 μM. CA-074 exhibits 10000-30000 times greater inhibitory effects on purified rat cathepsin B than on cathepsin H and L.
生物活性
CA-074是组织蛋白酶B (cathepsin B) 的有效抑制剂, Ki 值为2 to 5 nM。
安全信息
WGK Germany
3
海关编码
编辑结构
21-61263452 13641803416
中文名称:
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
英文名称:
CA-074
CAS NO.:
134448-10-5
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中文名称:
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
英文名称:
CA-074
CAS NO.:
134448-10-5
400-0707518  0512-58900862
中文名称:
L-TRANS-EPOXYSUCCINYL-ILE-PRO-OH PROPYLAMIDE
英文名称:
CA-074
CAS NO.:
134448-10-5
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