KB-5492 (200 mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage Dosage: 200 mg/kg Administration: Oral gavage Result: Reduced the lesion length as compared with the control. Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
体外研究
KB-5492 (0.001-100 μM) inhibits specific [ 3 H]DTG binding in a concentration-dependent manner. KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51 Cr release from gastric epithelial cells.
编辑结构
