1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats.
Animal Model:
Thirty rats.
Dosage:
1% HA in diet.
Administration:
Diet.
Result:
Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment.
A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.
Seven animals of the group died spontaneously or were sacrificed upon becoming
moribund between 335 and 462 days.
A total of 21 rats of group 1 survived until the end of experiment (mean value of total
intake of HA/rat was 76.8 g).
编辑结构
