Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.
体外研究
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.
Western Blot Analysis
Cell Line:
THP-1 cells and bone marrow macrophages
Concentration:
10 μM
Incubation Time:
74 hours
Result:
Enhanced β-arrestin2 and its interaction with IκBα.
RT-PCR
Cell Line:
THP-1 cells and bone marrow macrophages
Concentration:
10 μM
Incubation Time:
74 hours
Result:
Led to downregulation of NF-κB.
编辑结构
