TGF-beta

SRI-011381 hydrochloride protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 hydrochloride (10-75 mg/kg; p.o.; 14 days) results in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin. SRI-011381 hydrochloride (30 mg/kg; i.p.) activates TGF-β signaling in SBE-luciferase bioluminescent reporter mice. SRI-011381 hydrochloride is rapidly absorbed after oral administration to FBV mice with an oral bioavailability of approximately 50%. SRI-011381 hydrochloride reduces neurodegeneratio in APP751Lon, Swetransgenic mice. Animal Model: FBV mice Dosage: 10 mg/kg, 30 mg/kg, 75 mg/kg Administration: Oral administration; 14 days Result: Resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin

SRI-011381 hydrochloride promotes fibrillar Aβ clearance by macrophages, as demonstrated by the dose-dependent decreases of Aβ in the conditioned medium derived from compound-treated macrophages. SRI-011381 hydrochloride (10 μM) eliminates Saikosaponin A (SSA, 30 μM)-induced protective effects on fibroblasts.

SRI-011381 hydrochloride 是有口服生物活性的 TGF-beta 信号通路的激活剂，具有神经保护作用。