GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test. Animal Model: Male SD rats (200-300 g and 300–350 g) Dosage: 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg Administration: Oral gavage Result: Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test.
体外研究
GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production. Cell Viability Assay Cell Line: Rat hippocampal neurons Concentration: 0.1 µM, 1 µM, 10 µM Incubation Time: 1 hour Result: Prevented the ethanol (75 mM, 4 days) -induced MTT reduction.
编辑结构
