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化合物 T21557

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编辑结构

化合物 T21557

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CAS No. 1956426-56-4

分子式 C26H30Cl2N2O4S

分子量 537.5

英文名称 KN93 hydrochloride

中文同义词钙离子/钙调蛋白依赖激酶II(CAMKII)抑制剂(KN-93 HYDROCHLORIDE);化合物 T21557

基本信息

产品名称

化合物 T21557

中文同义词

钙离子/钙调蛋白依赖激酶II(CAMKII)抑制剂(KN-93 HYDROCHLORIDE),化合物 T21557

英文名称

KN93 hydrochloride

英文同义词

KN 93 hydrochloride;KN-93 (hydrochloride);KN93 hydrochloride;KN-93 HCl;CS-1449;KN93 (HCI);KN-93 (HCI);KN-93 HCI

CAS No.

1956426-56-4

分子式

C26H30Cl2N2O4S

分子量

537.5

EINECS号

MDL NO.

MOL

1956426-56-4.mol

性质

形态

结晶固体

颜色

白色至米白色

储存条件

Store at -20°C

溶解度

DMF:10.0(最大浓度 mg/mL);18.6(最大浓度 mM) DMSO:20.5(最大浓度 mg/mL);38.14(最大浓度 mM) 水:0.45(最大浓度 mg/mL);0.84(最大浓度 mM)

用途

靶点

Ki: 370 nM (CaMK-II)

体外研究

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.

生物活性

KN-93 hydrochloride是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，Ki 为370 nM。

编辑结构

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