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戊曲酯

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戊曲酯

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CAS No. 18296-44-1

分子式 C22H30O8

分子量 422.47

英文名称 Valtrate

中文同义词缬草三酯;[(1S,6S,7aS)-4-(乙酰氧甲基)-1-(3-甲基丁酰氧基)螺[6,7a-二氢-1H-环戊并[c]吡喃-7,2'-环氧乙烷]-6-基] 3-甲基丁酸酯;戊曲酯;环氧戊喃;缬草三酯(缬草素、环氧戊喃);戊曲酯,缬草三酯;VALEPOTRIATE 缬草三酯;戊曲酯/缬草素

基本信息

产品名称

戊曲酯

中文同义词

缬草三酯,[(1S,6S,7aS)-4-(乙酰氧甲基)-1-(3-甲基丁酰氧基)螺[6,7a-二氢-1H-环戊并[c]吡喃-7,2'-环氧乙烷]-6-基] 3-甲基丁酸酯,戊曲酯,环氧戊喃,缬草三酯(缬草素、环氧戊喃),戊曲酯,缬草三酯,VALEPOTRIATE 缬草三酯,戊曲酯/缬草素

英文名称

Valtrate

英文同义词

HalazuchroMe B;ValepotriatuM;ValtratuM;VALTRATE(P);[(1S,6S,7aS)-4-(Acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate;Valtrate;(1S,7R)-4-Acetoxymethyl-6,7aα-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1α,6α-diol 1,6-bis(3-methylbutanoate);VALTRATE(P)(PLEASE CALL)

CAS No.

18296-44-1

分子式

C22H30O8

分子量

422.47

EINECS号

242-174-2

MDL NO.

MFCD00868024

MOL

18296-44-1.mol

性质

密度

1.22±0.1 g/cm3(Predicted)

形态

Oil

沸点

525.9±50.0 °C(Predicted)

颜色

Pale Brown to Dark Yellow

储存条件

Refrigerator

溶解度

Chloroform (Slightly, Sonicated), Methanol (Slightly)

用途

用于含量测定/鉴定/药理实验等。

体内研究

Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.

化学性质

黄色液体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于蛛蛛香，缬草。

生物活性

Valepotriate, 从 Valeriana jatamansi 分离而来，具有抗癫痫和抗癌活性。

安全信息