体内研究
The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s.c.).
Animal Model:
Male Lister Hooded rats (56-63 postnatal day)
Dosage:
5, 10, 20, and 40 mg/kg
Administration:
Subcutaneously
Result:
Two doses (10 and 20 mg/kg) were highly significant in improving the extradimensional shift deficit induced by either treatment regimes.
Two doses (5 and 40 mg/kg) was ineffective at reversing the extradimensional impairment induced by the sub-chronic postnatal phencyclidine treatment regime.
编辑结构
