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4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
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基本信息
性质
用途
安全信息
编辑结构
4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
查看27 家供应商 暂无价格
CAS No. 152121-53-4
分子式 C20H13FN4O2
分子量 360.34
英文名称 PD 169316
中文同义词 4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
基本信息
产品名称
4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
中文同义词
4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
英文名称
PD 169316
英文同义词
PD 169316, >97%;CS-497;PD 169316 - CAS 152121-53-4 - Calbiochem;4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-4-yl]pyridine;Pyridine, 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-iMidazol-5-yl]-;PD169316/PD-169316;4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine;4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine PD 169316
CAS No.
152121-53-4
分子式
C20H13FN4O2
分子量
360.34
EINECS号
200-256-5
MDL NO.
MFCD12405019
性质
密度
1.354±0.06 g/cm3(Predicted)
形态
solid
沸点
583.1±50.0 °C(Predicted)
颜色
light orange
溶解度
DMSO: >10mg/mL
储存条件
2-8°C
酸度系数(pKa)
9.09±0.10(Predicted)
用途
靶点
TargetValue TGF-β () Activin A () Enterovirus71 () p38 MAPK (Cell-free assay) 89 nM
体内研究
PD169316 (1 mg/kg, intramuscular injection every day for 14 consecutive days) shows antiviral activity in a suckling mouse model. Animal Model: EV71-challenged suckling mouse model (7-day-old Kunming mice). Dosage: 1 mg/kg. Administration: Intramuscular injection every day for 14 consecutive days. Result: Showed antiviral activity.
体外研究
PD169316 (10 μM) inhibits TGFβ and Activin A, but not BMP4 signaling in CaOV3 cells. PD169316 (0.2-20 μM) inhibits TGFβ-induced Smad2 nuclear translocation, Smad7 mRNA induction, and reporter gene activity in CaOV3 cells. PD169316 (10 μM) shows a significantly increased rate of proliferation in Nestin knockdown cells, and can rescue the effect of Nestin knockdown on cell viability in the absence of EGF. PD169316 significantly inhibits p38 MAP kinase activity with no significant change in ERK activity in PC12 cells. PD169316 (10 μM) blocks apoptosis induced by trophic factor withdrawal in differentiated PC12 cells.PD169316 (10 μM, 30 min) selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. Increased phospho p-38 levels in the presence of PD169316 are most likely due to blockade of negative feedback loop of dephosphorylation of p38 MAPK by MAPK phosphatases. Western Blot Analysis Cell Line: Ishikawa PRB or PRA cells. Concentration: 10 μM. Incubation Time: 30 min. Result: Did not inhibit MEKK1-induced p38 phosphorylation.
生物活性
PD 169316 是一种有效的、细胞可渗透的选择性 p38 MAP kinase 抑制剂,IC50值为89 nM。 PD169316 可消除 TGFbeta 和 Activin A 引发的信号传导。 PD169316对 Enterovirus71 具有抗病毒活性。
安全信息
WGK Germany
3
安全说明
海关编码
危险品标志
Xn
危险类别码
危险品运输编号
UN 2811 6.1/PG 3
编辑结构
13581984929 010-010-62452898
中文名称:
4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
英文名称:
PD 169316
CAS NO.:
152121-53-4
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15666160102 0530-0530-5296766
中文名称:
4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
英文名称:
PD 169316
CAS NO.:
152121-53-4
联系我们:
QQ
QQ号: 598142694 复制
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4000665055  021-50795510
中文名称:
4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
英文名称:
PD 169316
CAS NO.:
152121-53-4
联系我们:
QQ
QQ号: 2881685224 复制
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