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ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

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编辑结构

ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

查看2 家供应商

暂无价格

CAS No. 142439-94-9

分子式 C10H13N5NaO5PS

分子量 369.27

英文名称 ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

中文同义词

基本信息

产品名称

ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

中文同义词

英文名称

ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

英文同义词

SP-CYCLIC 3,5-HYDROGEN PHOSPHOROTHIOATE ADENOSINE SODIUM SALT;RP-CAMPS NA;RP-CAMPS SODIUM SALT;ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT;ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT;CAMPS NA RP-ISOMER;Rp cAMPS sodium salt,RpcAMPS sodium salt

CAS No.

142439-94-9

分子式

C10H13N5NaO5PS

分子量

369.27

EINECS号

MDL NO.

MOL

142439-94-9.mol

性质

形态

固体

颜色

白至粉红

储存条件

Store at -20°C, sealed storage, away from moisture and light

用途

靶点

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)

体内研究

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.

体外研究

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.

生物活性

Rp-cAMPS sodium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。

编辑结构

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