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2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)

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2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)

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CAS No. 112898-15-4

分子式 C30H39N6O15P3

分子量 816.58

英文名称 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT

中文同义词腺苷 5'-(三磷酸四氢酯) 3'-(4-苯甲酰基苯甲酸酯) 三乙胺盐;2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C);2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐;化合物BZATP TRIETHYLAMMONIUM SALT;2′(3′)-O-(4-苯甲酰苯甲酰)腺苷5′-三磷酸三乙铵盐

基本信息

产品名称

2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)

中文同义词

腺苷 5'-(三磷酸四氢酯) 3'-(4-苯甲酰基苯甲酸酯) 三乙胺盐,2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C),2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐,化合物BZATP TRIETHYLAMMONIUM SALT,2′(3′)-O-(4-苯甲酰苯甲酰)腺苷5′-三磷酸三乙铵盐

英文名称

2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT

英文同义词

2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT;2'-3'-O-(4-benzoylbenzoyl)adenosine*5'-triphospha;2'-3'-O-(4-BENZOYLBENZOYL)ADENOSINE5'-TR IPHOSPHATE;BENZOYLBENZOIC ADENOSINE 5'-TRIPHOSPHATE;2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphatetri(triethylammonium)salt;2'(3')-o-(4-benzoylbenzoyl)adeno;Adenosine 5'-(tetrahydrogen triphosphate) 3'-(4-benzoylbenzoate) compd. with N,N-diethylethanamine;2'(3')-o-(4-benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt

CAS No.

112898-15-4

分子式

C30H39N6O15P3

分子量

816.58

EINECS号

MDL NO.

MFCD00058547

MOL

112898-15-4.mol

性质

形态

solid

颜色

white to off-white

InChIKey

HVOVBTNCGADRTH-WBLDMZOZSA-N

溶解度

≤14 mg/ml in DMSO

储存条件

-20°C

用途

靶点

pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7) EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)

体内研究

BzATP (5 mg/kg) significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction. Animal Model: Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g) Dosage: 5 mg/kg Administration: Injected through the intraperitoneal route Result: At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively.

体外研究

BzATP (10-1000 μM; 24 h) promotes the proliferation and migration of U87 and U251 glioma cells. P2X7R protein expression is induced by BzATP (100 μM; 6-48 h) in human glioma cells. Cell Proliferation Assay Cell Line: U87 and U251 glioma cells Concentration: 5, 10, 50, 100, 500 and 1000 μM Incubation Time: 2, 6, 12, 24, 48 and 72 hours Result: The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively. The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM. The optimal incubation time is 24 hours in both U87 and U251 cells lines. Western Blot Analysis Cell Line: U87 and U251 glioma cells Concentration: 100 μM Incubation Time: 6-48 hours Result: Induced the upregulation of P2X7R.

生物活性

BzATP triethylammonium salt 是一种 P2X 受体激动剂，对 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分别为 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium salt 对 P2X7 受体有效，对大鼠 P2X7 和小鼠 P2X7 的EC50 分别为 3.6 μM 和 285 μM。

安全信息