Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice. Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice. Animal Model: Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days Dosage: 1 mg/kg Administration: I.p. three times a week for 7-90 days Result: Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment. Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.

Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity. Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells.

Splenopentin diacetate 是一种合成的免疫调节性五肽，对应于脾脏激素脾脏蛋白的残基 32-36。Splenopentin diacetate 可影响早期的 T 细胞和 B 细胞分化，从而增加 γ 射线照射后小鼠体内抗体形成细胞的数量。